Friday, March 1, 2013

Thursday, February 28, 2013

Has Ted Cruz Hit The Tipping Point?

ABC's Michael Falcone reports:

The Ted Cruz headlines just won't stop.

"Sen. Ted Cruz says Obama wants immigration bill to fail to hurt GOP," wrote the Dallas Morning News last week. Another Texas paper, the Houston Chronicle, published a recent piece titled: "Ted Cruz: The next Reagan or the next Joe McCarthy?"

Politico carried this on their homepage: "Ted Cruz defends his blunt style." And Salon ominously foreshadowed, "The coming Rand Paul-Ted Cruz brawl."

In recent weeks the freshman senator from Texas has been the subject of a profile in The New York Times, which dubbed him "Washington's new bad boy," and in the New Yorker, which surfaced a speech he delivered in 2010 accusing a dozen members of the Harvard Law School faculty of being communists. (Cruz is a Harvard Law School graduate). Earlier this month, CNN's chief Congressional correspondent Dana Bash traveled to Texas to interview Cruz and so did the Christian Broadcasting Network's David Brody.

Without a doubt, Cruz has attracted more attention than any other freshman member of Congress from either party in the opening months of the 113th Congress. The Republican lawmaker made waves for his blunt questioning of Defense Secretary nominee Chuck Hagel during his confirmation hearings, and he has been embraced by conservative leaders seeking a new hero.

He has been hailed by the Tea Party Express as a politician who is "shaking up Washington, D.C. just like he promised" and by another political action committee, the Senate Conservatives Fund, as someone who is "showing Washington what courage looks like."

And that is almost exactly how Cruz sees it too.

"I made promises to the people of Texas that I would come to Washington to shake up the status quo," Cruz recently wrote to The New York Times and Politico in response to a list of e-mailed questions. (The Texas Republican declined to grant interviews to either publication).

"Ted's always been ambitious, he's always been arrogant," said one Republican strategist who has known Cruz since before coming to Washington. "I think the honest truth is, he's doing exactly what he's said he was going to do when he campaigned."

But keeping his promise has also earned him his share of criticism - and not just from those on the other side of the aisle - from prominent fellow Republicans too.

Sen. Lindsey Graham of South Carolina called some of the questions Cruz posed to Hagel "out of bounds" and Sen. John McCain of Arizona told The Times' Jonathan Weisman in an interview that "the appropriate way to treat Senator Hagel is to be as tough as you want to be, but don't be disrespectful or malign his character" (implying that Cruz had fallen short of that standard). Democrats piled on too.

In an interview on Tuesday with the Texas Tribune, Cruz defended his conduct at the Hagel hearings, saying he "focused on substance and, in particular, Mr. Hagel's policy record."

"It has not focused on personal issues, and, indeed, the character attacks that have been raised have been leveled at me for asking questions that I think every senator should be concerned to know the answer," he told the Tribune's Emily Ramshaw.

Cruz has won prominent advocates for his take-no-prisoners style.

"Most politicians know what to say to get elected but then arrive in Washington with no real spine - or in many cases, no intention of ever doing what they promised," former Sen. Jim DeMint, a conservative icon who now heads the Heritage Foundation, wrote in a Politico Op-Ed. "Not Cruz. He's proved himself an effective advocate for the founding principles that made our nation great: personal freedom and responsibility, local control and adherence to the law as it is written, not the way some politicians wish it was written."

And the junior senator from Texas has already achieved a certain iconic status himself. A Texas Republican who filed paperwork to mount a primary challenge to incumbent GOP Sen. John Cornyn told the Daily Caller that Cruz is an inspiration to him.

"If I'm trying to describe somebody who I would best mimic, it would be Sen. Cruz," the challenger, Erick Wyatt, told The Daily Caller's Alexis Levinson. (Regardless of Wyatt's compliment, reports have suggested a close political alliance between Cruz and Cornyn).

Those who know him say Cruz has been more than happy to take full advantage of his time in the spotlight, but the freshman lawmaker who previously served as solicitor general of Texas, emphasized in an interview with the Christian Broadcasting Network's David Brody that he is taking all of the new-found attention in stride.

"I try to pay, pay very little attention to the media," he said. "It is, as you know, a fickle creature."

Notably, Cruz's approach represents a marked contrast to that of another prominent Republican, Florida Sen. Marco Rubio, who started out his career in the U.S. Senate quietly. In 2011, Rubio spent his first months in Washington mostly out of the public eye. Since then, of course, he has become a major player in the Republican Party, emerging as a key voice in the immigration reform debate and stoking speculation about a potential 2016 presidential run.

With Cruz and Rubio's stars rising fast, one Texas GOP insider predicted that the U.S. Senate may eventually not be big enough for the both of them: "At some point the fire hydrant is going to get crowded, and we'll see who marks it."

Also Read

Source: http://news.yahoo.com/ted-cruz-hit-tipping-point-not-pub-153606221--abc-news-politics.html

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Friday, February 22, 2013

Promising new method for next-generation live-attenuated viral vaccines against Chikungunya virus

Feb. 21, 2013 ? Researchers have successfully applied a novel method of vaccine creation for Chikungunya virus (CHIKV) using a technique called large scale random codon re-encoding. Using this approach, a group from the UMR_D 190, Emerging viruses Department in Marseille, France in collaboration with the University of Sydney, Australia, demonstrated that the engineered viruses exhibit a stable phenotype with a significantly decreased viral fitness (i.e., replication capacity), making it a new vaccine candidate for this emerging viral disease.

This new report publishes on February 21 in the Open Access journal, PLOS Pathogens.

There is an immense need for the development of vaccines targeting many emerging viral pathogens. CHIKV has been responsible for several million human cases over the last decade and represents a striking example of a re-emerging, arthropod-borne, human pathogen for which no licensed vaccine exists. Worryingly, one of the vectors of CHIKV, the mosquito Aedes albopictus, has dispersed into new regions (including temperate areas) resulting in outbreaks of this disease where they had never been previously observed, for example in Italy.

Using the large-scale codon re-encoding method, Antoine Nougairede and colleagues were able to synthetically modify the nucleic acid composition of the virus without modifying the encoded viral proteins. When this method was applied to poliovirus and Influenza A virus, it resulted in a live but attenuated virus that had significant reduction of viral fitness. In contrast with previous studies, which employed a targeted approach of codon re-encoding, this new study demonstrates that a random approach reduced the replicative fitness of CHIKV in both primate and arthropod cells. The employed strategy also prevented the reversion of the attenuated phenotype by mutation or recombination, thus reducing the possibility that the newly created virus strain could evolve back to the pathogenic version.

The findings by Nougairede et al. suggest that large-scale codon re-encoding can provide a strong basis for the rapid design of next-generation viral vaccines against emerging viral pathogens, as soon as their genome sequence has been determined. It represents an exciting route to vaccine development because it intrinsically alleviates the likelihood of novel pathogenic properties of the designed live vaccine, and allows modulation of the amount of reduced fitness by altering the terms and degree of the genetic re-encoding. Thus, this strategy potentially allows for the generic development of live attenuated vaccines against many new viral pathogens, with reduced costs and the potential single dose induction of long-term immunity.

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Story Source:

The above story is reprinted from materials provided by Public Library of Science.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Antoine Nougairede, Lauriane De Fabritus, Fabien Aubry, Ernest A. Gould, Edward C. Holmes, Xavier de Lamballerie. Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells. PLoS Pathogens, 2013; 9 (2): e1003172 DOI: 10.1371/journal.ppat.1003172

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/ZfDSqDFNAto/130221194235.htm

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Gov't downsizes amid GOP demands for more cuts (The Arizona Republic)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/286584416?client_source=feed&format=rss

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Thursday, February 21, 2013

Mayock: Texas DE Okafor in second-third round - Alex Okafor (DL) Texas Longhorns

CollegeBasketballTalk

College hoops news and rumors
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Source: http://www.rotoworld.com/content/playerpages/player_main.aspx?sport=CFB&id=130706

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Television section

For the week of Jan. 21-27

1. "American Idol" (Wednesday), Fox, 16.07 million.

2. "American Idol" (Thursday), Fox, 15.65 million.

3. "NCIS," CBS, 12.86 million.

4. Pro Football: Pro Bowl, NBC, 12.16 million.

5. "NCIS: Los Angeles," CBS, 11.93 million.

6. "Criminal Minds," CBS, 11.84 million.

7. "60 Minutes," CBS, 11.65 million.

8. "2 Broke Girls," CBS, 11.56 million.

9. "The Big Bang Theory," CBS, 11.49 million.

10. "CSI: Crime Scene Investigation," CBS, 11.46 million.

Source: http://www.today.com/id/3032450/ns/today-entertainment/

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Steve Price subdivides his head for cancer charity

Former Warriors captain Steve Price is "subdividing" his head as a novel way to raise more money for the Child Cancer Foundation with a social media drive launched this afternoon.

The rugby league legend ??who is Queensland's most-capped State of Origin forward ??is an ambassador of the Child Cancer Foundation and each year hosts a charity dinner as a fundraiser.?

This year he is shaving his head to raise money for the cause, but to maximise what he can raise he is "subdividing" his head into sections.?

People who want to sponsor him can bid on the sides, front, top or back of his head.?

To help raise awareness, he will be using Twitter to drum up support under the hash tag #priceyrealestate.

The winning bidders will be hosted by Steve at his star-studded Child Cancer Foundation Dinner in Auckland on Friday, March 1.?

callison@nbr.co.nz

Source: http://www.nbr.co.nz/article/steve-price-subdivides-his-head-cancer-charity-ca-136260

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