Yesterday,?11:46 PM #2??
2013 is just getting rolling, still a long way to go... |
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Source: http://forums.crackberry.com/blackberry-q10-f272/q10-z10-android-iphone-windows-765785/
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"The former Iowa advisor for Mitt Romney's presidential campaign said the Republican party should heed the demographic shift on issues like marriage equality.
"Frankly, the culture wars are kind of over," Dave Kochel told WHO-TV on Sunday. "And Republicans largely lost."*
According to a Romney advisor, not only are the "culture wars" over, but Republicans lost handedly, thanks to their stance on limiting gay marriage rights. Have the tides truly changed? Is the nation in agreement over gay rights? Or is there something else at play? Cenk Uygur breaks it down.
*Read more from Raw Story (http://s.tt/1z3mq)
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Source: http://www.youtube.com/watch?v=ToYxu-10pR0&feature=youtube_gdata
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NanoProfessor, one of the branches of NanoInk, Inc. dedicated to the education related to nanotechnology, has declared that North Central State College of Ohio has included nanotechnology to their science curriculum. The north central college has purchased the 'NanoProfessor' which is an Educational Program curriculum of Nano science.
Ken Ekegren, who is an Assistant Professor of Engineering Technology, was granted with an Innovation Fund donation from the NC State Foundation to invest in the nanotechnology educational program. Professor Ekegren opined that "Incorporating nanotechnology in the engineering and bioscience programs is a major decision, which will make our students ready to compete for highly specialized positions in every field. He further added that the NanoProfessor curriculum will be integrated in the Engineering Materials class and will provide students with an understanding about nanoscience and its application.
Dean Hart, the Chief Commercial Officer of NanoInk said that "It is our pleasure to declare that North Central State College is the first school in Ohio to add the NanoProfessor into its ongoing science and engineering curriculum and we will be delighted to work with NC State for growing its nanotechnology focus.
North Central State College is a community centered educational organization offering supreme quality technical education to the citizens of north central Ohio.
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By: Jeff Buckingham
Summary: VOIP or ?Voice Over Internet Protocol? is applied to a wide range of services that convert voice telephone calls to a stream of data which can be passed over Private Networks or the Internet.? This technology can be very useful when integrated in an overall telecommunications plan.? However, for many reasons, this may not be the best solution for all businesses. VOIP can be costly, complicated and can reduce overall call quality.? However, VOIP can also provide many new features and reduce costs over time. Before making a decision to move to VOIP, make sure you fully understand your communication needs and how VOIP service may help support your business.
The three main areas of VOIP are: Business or Hosted VOIP, VOIP based Business Telephone Systems and Consumer VOIP.
1. Business VOIP services such as hosted PBX ? A hosted PBX is a telephone system that is housed outside of the customer?s office in the provider?s network and is becoming popular in the work place. The customer uses an Internet connection and VOIP telephones connected to their local area network. The advantage of these services can be a fixed cost per month with unlimited calls, as well as using the same telephone system for employees with common voice mail and dialing plans.
The disadvantage of these services can be service outages caused by the customer?s local area network, the Internet connection, or the hosted PBX provider. It is also often difficult to diagnose the source of the service outages, resulting in frustration for the customer and service provider. The highest-quality hosted PBX providers will provide their own Internet connection and often insist on managing the customer?s local area network so they can make sure that service works properly. Some customers save money with hosted PBX but many do not due to the cost of local area network upgrades. These systems need to be looked at on a case by case basis.
2. VOIP based business telephone systems ? These systems place the telephone hardware at the customer?s office. The features are very similar to a hosted PBX and the telephone lines can be VOIP based (called SIP trunks) or traditional telephone lines. The initial cost of these systems is often 20 to 50% higher than a traditional telephone system but there are long term savings on maintenance. For example; employees can simply plug their phone into any network jack in the office. There is often a requirement for upgrade or replacement of the local area network equipment for these systems to function properly.
VOIP based business telephone systems are growing rapidly in business telecommunications and there is no question that this trend will continue. In spite of the popularity there are many customers who have experienced significant service interruptions due to poorly planned installations. Even the best installations do tend to have a higher incidence of occasional unexplained technical problems. It is highly recommended that business installations be handled by a trained professional with a past record of successful installations. Make sure that thorough reference checks are performed on any vendors before the project is implemented, and that the system is fully tested under real life conditions before the installers leave the building.
3. Consumer VOIP services ? These are free or low cost services such as Skype, Vonage, or Google Voice. Typically, these are used for saving money on long distance telephone calls.? These services are especially popular for placing international calls. Skype is also used as a video conferencing service. These services often do save money but the quality of calls can vary since the provider has no control over the user?s Internet connection. If you can tolerate poor connection quality or can place another call over a regular telephone line when VOIP call quality is poor, this service may be of interest to you.?
These services do work especially well for businesses to save money when an employee is located in another country. The amount of money saved is usually significant compared to buying traditional telephone service.? However, most businesses telephone conversations are important and the cost of lost calls or poor communication can far outweigh the savings. Long distance calling rates have come down significantly in the past few years, so a regular telephone line may end up being a better option even for international calls.
What?s the right decision for me?
Businesses often think that if they aren?t using the latest technology, they are falling behind their competition. This may be true, but not all new technologies are the best choice for all situations.? Many people assume that VOIP services are ?cheap?, but VOIP services can actually be more expensive in some business applications.? Additionally, communications over a VOIP phone system may be ?choppy? and difficult to understand due to poor data transmission and poor quality Internet connections.? Most businesses cannot tolerate these disruptions to quality communication within their organization. In other words, poor call quality can also be very expensive by reflecting negatively on your business.? If you have employees scattered all over the world, VOIP may be a great way to be connected. But for most businesses, traditional phone services including the integration of VOIP applications as needed, may be the best option for affordable, consistent, high quality phone service.
Who can you contact to help you through the process?
If you have questions or would like to discuss VOIP options for your office, please feel free to contact Blue Rooster Telecom at 805-543-8700 or visit our website at www.blueroostertelecom.com
Want to learn more about Blue Rooster Telecom?
Blue Rooster Telecom is a San Luis Obispo-based telecom carrier offering voice, VoIP, Internet, and data services. Its customers are always first, as the company sets the highest standards for customer service, delivering reliable products and creating custom solutions. Some of Blue Rooster Telecom?s employees have over 30 years of telecommunication experience, with a passion to be dependable, professional and friendly when working with any client. For more information, visit www.blueroostertelcom.com or like them on Facebook at www.facebook.com/blueroostertelecom
Tags: Business Telecom SLO, Business Telephone Lines, Jeff Buckingham, San Luis Obispo, VOIP
Source: http://www.blueroostertelecom.com/blog/2013/01/29/should-i-be-using-voip-in-my-business-2/
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The gay community gasped in unison on Monday afternoon, when the Senate revealed an immigration plan that did not include same sex couples. Don't worry gay community. Barack Obama's got you covered. At least according to several of BuzzFeed's sources, he does.
RELATED: Pundits Agree: It's The Wrong Time for Immigration Reform
On Monday night, BuzzFeed's Chris Geidner and Zeke Miller reported that Obama would indeed include same sex couples in his immigration reform package. In their own words: "A Democratic source said, 'Same-sex couples will be part of his proposal.' A second source confirmed that, unlike the Senate framework released Monday, same-sex bi-national couples -- those with one American and one foreign partner -- will be included in the White House principles." This means that, if Obama does make the change and if the proposal makes it through Congress, same-sex couples would have equal rights as heterosexual couples on crucial issues like green cards.
RELATED: Governor Martinez: Illegal Immigration Okay for Me, Not for You
This would be a very presidential move for the president -- decisive, direct and somewhat demanding. After all, the folks on Capitol Hill have so far been super ambivalent about the issue. It was not included in the final proposal, but lawmakers had discussed including same sex couples in the new set of laws. However, when asked why the initial proposal lacked LGBT provision. Sen. John McCain, one of four Republicans working on the proposal simply said, "We'll be working out those details."?Rep. Jerrold Nadler was a little more opinionated about the issue, calling it "madness" that same sex couples were left out, a "major omission."
RELATED: North Carolina (Quietly) Moves to Ban Gay Marriage Forever
No matter what happens from here on out, it's becoming apparent that the gay rights movement is about to latch on to the push for immigration reform. And why shouldn't they? The point of reform is to fix things that are broken, and as the country moves towards greater equality for people of all sexual orientations, why should same sex couples be left out? Well, it could get tricky. If the conversation turns too sharply in the direction of gay rights, the larger immigration reform process could get bogged down or even stuck in the mud completely. Let's leave the ifs alone for now, though, and see what the president actually does.?
Source: http://news.yahoo.com/obamas-immigration-reform-front-gay-rights-battle-041633557.html
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Liked what you saw? Even happier then, as a Brit, you'll likely be getting your hands on it months before your US cousins. UK networks have started to announce availability for the handset, with EE, O2, Three and Vodafone already confirmed to be stocking the Z10. Retailers that will also be selling the new BB10 hardware in the British Isles include Carphone Warehouse and Phones 4U.
Retailer Phones 4U will launch both color options (exclusively, at least initially) although it hasn't ventured a contract-free price just yet. The Carphone Warehouse, meanwhile will be offering the Z10 free on contracts of £36 per month on the major networks.
Vodafone will offer the Z10 for £29 on the £42 a month Red Data plan, including unlimited calls and texts as well as 2GB of internet. It'll be free on the £47 a month variant of plan, or cost £69 one-of payment on the £37 per month plan. Three UK hasn't revealed any details beyond that it'll be stocking the handset.
While all Z10 devices sold will be ready for 4G, according the Waterloo crew, the BlackBerry Z10 will be available to utilize EE's existing 4G service immediately. The price? It'll be £50 on a £41 per-month 24 month package, with 1GB of mobile data, as well as unlimited UK calls and texts. No word just yet on whether Orange and T-Mobile will be offering cheaper bundles later. We'll update here when we hear more pricing details from the other players.
Filed under: Cellphones, Mobile, RIM
Source: http://www.engadget.com/2013/01/30/blackberry-z10-uk-pricing/
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The Mio Alpha made a bit of a splash on Kickstarter earlier this year when it promised a heart rate-sensing watch that didn't use chest straps or similar encumbrances to measure your exertion. They went $200,000 over their goal of $100,000 and just started shipping in time for pre-marathon season.Source: http://feedproxy.google.com/~r/Techcrunch/~3/fA9R1wFw4Cc/
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This new spicy chilli tomato pickle is made from ripe tomatoes, fresh chillies, garlic, ginger, mustard oil and seeds plus a selection of herbs and spices.
Realising the UK market was lacking a premium pickle, Michael Sohel, former Investment Bank Business Manager decided to create the range to bring an Indian-style pickle to the UK market.
Lovepickle is available in four strengths
Lovepickle is available in four strengths ? Mild, Medium, Hot and Extra Hot. Mild is designed to be served as a dip for those who prefer a gentle spice, while Medium offers a stronger, spiced flavour.
Lovepickle Hot is tangy and designed for adding an extra fiery flavour to meals and Extra Hot is for those who enjoy a full-on spicy kick.
Positioned as a premium product, Lovepickle can be eaten with Indian foods such as poppadoms and naan bread or as an accompaniment to main courses.
It can also be eaten with a wide range of meals and dishes as a condiment and as an alternative to chutneys, relishes and ketchups.
Following a soft launch in summer 2012, Michael is now launching the product nationally and welcomes enquiries from retailers looking to stock this exciting new pickle brand.
Michael Sohel, founder of Lovepickle, said:
?The British palate is accustomed to spicy foods and many consumers enjoy spicing up their meals and snacks.
?The great thing about Lovepickle is that it?s so versatile ? it can be used as a dip or be served as a condiment alongside Indian dishes, with cheese and crackers, in sandwiches, and with main courses such as meat and fish.
?Encouragement from family and friends has led me to embark on this venture and to share a pickle that I have enjoyed for many years.
?Over the last year, I have developed the family recipe and brand following extensive research in the marketplace and consumer trials.
?I am passionate and excited about Lovepickle and truly believe that the result is a quality product that delivers on taste, texture and appearance that Indian and spicy food fans will enjoy as an accompaniment to a variety of foods.
?I am delighted to be introducing the Lovepickle range and I?ve had some great feedback from customers already. It?s a huge landmark as I venture into the retail product sector and will be extending the range during 2013.?
Lovepickle Mild, Medium, Hot and Extra Hot is available in cases of 24 x 180g jars with an RRP of ?2.95 to ?3.25 per jar.
It is an ambient product and has a shelf life of 12 months.
The product does not contain any added colours, flavours or preservatives.
The full range is available to multiple and independent retailers, specialty food stores, delis as well as fine food shops and markets.
Click here for more information.
Source: http://www.fdin.org.uk/2013/01/new-lovepickle-brand-adds-to-uk-condiment-sector/
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According to reports, Queen Beatrix of The Netherlands is expected to abdicate in favour of her son Prince Willem-Alexander.
By Reuters
Update: 1:41 p.m.
?Dutch Queen Beatrix, who turns 75 on Thursday, announced she was abdicating in favor of her son, Prince Willem-Alexander, who will become king on April 30.
Willem-Alexander, 45, is married to Princess Maxima Zorrigueta and has three young children. Decades of grooming for the throne involved shaking off his image as a beer-drinking fraternity boy whose blunt comments upset the press and politicians.
Beatrix said in a television broadcast to the nation that she was stepping down because she felt her son was ready to take her place on the throne.
A constitutional monarchy, the Netherlands had reduced the involvement of the Royal House in politics, a role long seen more as a formality than a position of power.
In the past, the Queen took part in forming government coalitions by appointing a political mediator, raising questions about behind-the-scenes influence on the democratic process.
That role was scrapped before the last election, which took place in September 2012.
It was widely rumored that Queen Beatrix was no fan of anti-immigrant, euroskeptic politician Geert Wilders. She alluded in speeches to the need for tolerance and multi-culturalism, comments that were seen as criticisms of Wilders' anti-Islamic views.
Wilders' poor showing at the last election and loss of influence in politics, could well have contributed to her decision to abdicate.
Queen Beatrix, who remains very popular with the Dutch, became the sixth monarch of the House of Orange in 1980 following the abdication of her mother, Queen Juliana, who reigned for 31 years.
Juliana was 73 years old and in deteriorating mental health when she abdicated but Beatrix has remained active and in good health despite some setbacks.
The queen was emotionally shaken when a man drove his car into a Queen's Day procession in 2009.
Her middle son, Prince Johan Friso, has been in a coma ever since he was buried in an avalanche while skiing last year.
More:
Source: http://theroyals.today.com/_news/2013/01/28/16739070-dutch-queen-expected-to-give-up-the-throne?lite
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When the electricity goes out or gets scarce, frequent business travelers like your boss know all the top tricks to power up, discovered freelance journalist Jane L. Levere.
Sales and marketing executive Mark Pearlstein never leaves for a trip without his 92-hour rechargeable backup battery from Brookstone, which he uses to refuel his laptop and smartphone on the go. It helps get business done on the road, but he found it most useful at home during Hurricane Sandy.
Pearlstein used the battery to power his smartphone, which he turned into a mobile hotspot, which delivered Internet to his laptop.
Most travelers have a knack for making do with the resources at hand, says Ron diLeo, executive di??rec??tor of the Association of Cor??por??ate Travel Executives.
?When you?re a frequent traveler, you learn how to charge your phone off your laptop until you can get to a place where you can charge the laptop,? he said.
Many frequent travelers also take advantage of the following gadgets:
? Adapted from ?Power Is Where You Find It,? Jane L. Levere, The New York Times.
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Vine, Twitter’s latest foray into video sharing, seems to be having some service issues at the moment. We’ve been trying to access and use the app here at TechCrunch with no progress, and Vine has tweeted to confirm the service issues. Vine launched last Thursday and has had a whirlwind of a week. Though relatively buggy for an app launched by a major company like Twitter, Vine was welcomed by the tech blogosphere as the next Instagram, as it lets you share six-second looping videos (with or without sound) to all your favorite social networks. However, the fun ended quickly as users noticed a slight porn problem on the app. A porn clip called “DildoPlay,” which showed up on the app’s Editors’ Picks section on Monday, made matters even worse. Twitter claims that the clip was chosen because of “human error.” Then, Apple removed Vine from the App Store’s Featured section, presumably after seeing that a porn clip had been featured within the app. Vine has since started censoring the app, filtering out searches for various porn-related search terms. Today, the string of obstacles gets a bit longer with the reported service outage. Vine is experiencing a temporary service interruption. Thanks for your patience. ? Vine (@vineapp) January 29, 2013 Is everyone looking for the newly-hidden pr0n on Vine all at once, because the service appears to be down. ? Eric Zeman (@phonescooper) January 29, 2013 We’ll be sure to update the post as soon as Vine is back up and running. Stay tuned. Update: It looks like service is back up for a few users, but Twitter has not confirmed that we’re at full stability yet. Update 2: As you can see from Vine’s Twitter stream, the service has been back and forth all day. As of 6:00pm EST, everything seems to be ok.Source: http://feedproxy.google.com/~r/Techcrunch/~3/V5pH3y1WCF4/
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12 hrs.
After four years of government prodding ? from federal stimulus spending to the Fed?s historic easy-money policies ? the U.S. economy finally?is showing signs of sustainable growth.?
But?it?s not out of the woods yet.
The hopeful signals are coming from a broad range of indicators - from upbeat reports on home and car sales to business investment and manufacturing orders. Those reports have raised hopes that the ongoing move to balance the federal budget with tax increases and spending cuts won?t dampen the emerging recovery.
?We think the U.S. economy will be able to power through that this year ? even with the drag,? said?Tony Fratto, an economist at Hamilton Place Strategies and former Treasury official under President George W. Bush.
But when Federal Reserve officials wrap up?their two-day meeting Wednesday, they?re widely expected to continue to keep their foot on the gas pedal by extending their aggressive program of holding interest rates near zero.?
Though some critics think it may be time for the central bank to begin winding down its epic easy-money strategy, Fed policy makers have already promised to stick with it until the unemployment rate falls below 6.5 percent. ?
The halting pace of the recovery is expected to be highlighted Wednesday when the government takes its initial estimate of the growth of gross domestic product for the last three months of 2012. Analysts polled by Reuters expect the report to peg expansion at a weak 1.1 percent annual rate, down from a 3.1 percent rate in the previous three months.
But a basket of separate reports this week is expected to confirm the marked pickup in growth as the year drew to a close.?
Orders for durable goods jumped by 4.6 percent in December, the?Commerce Department said Monday, more than double what private forecasters had expected. Though many business managers complained loudly that uncertainty in Washington had left them unwilling to take on new workers, they were busy investing in new plant and equipment to keep up with rising demand from customers.
?CEOs may have been worrying about falling off the cliff but demand for big-ticket items still soared,? said Joel Naroff, chief economist at Naroff Economic?Advisors.
The report followed wider signs of a broad pickup in demand throughout the economy. Rising home sales, which began to pick up in the second half of last year, continue to push prices higher, helping convince reluctant buyers and sellers that the market has finally bottomed out. ?
Car sales jumped 16 percent in the fourth quarter of last year compared to the previous year, and are on pace for another annual sales increase. Automakers will report monthly sales on Friday and are expected to post another month of robust demand. The prolonged sales downturn during the Great Recession left behind an aging fleet of cars and trucks that buyers are now replacing. ?
Despite a lackluster holiday shopping season, overall retail sales in the last three months of the year were up 6 percent from a year ago.?Manufacturers are also seeing a solid pickup in orders for new goods. Lower energy costs -- the result of an ongoing boom in natural gas production?--?have helped them win bids against low-cost foreign competitors.?
But unemployment remains stubbornly high, as the latest reading, due this Friday, is expected to show. Economists are looking for a net gain of just 163,000 new jobs for the latest month. That?s barely enough to keep up with population growth and not enough to move the needle of the unemployment rate which forecasters expect to remain stuck at 7.8 percent.
To be sure, the Fed?s easy money policy is helping some households ? especially those with investments in the stock market. With interest rates at near zero, investors looking for a positive return have few alternatives.?
Stocks are up 15 percent since June. In January alone, investors sank $55 billion in new cash into stock mutual funds and exchange-traded funds, the biggest monthly inflow on record, according to TrimTabs Investment Research.?
Fears of a financial meltdown in Europe have faded. Last year?s worries about a sharp slowdown in Asia have eased for now.?And despite continued threats of political disruption in Washington, the long-running battle over the federal budget seems to be inching toward resolution.
On Monday, credit rating agency Fitch said last week?s deal to delay suspension of the country's debt limit have reduced the odds that it might strip United States of its AAA rating. Another rating agency, Standard and Poor?s, cut the U.S. debt rating one notch after the last debt ceiling debacle in July 2011 pushed the Treasury to the brink of defaulting on its bonds.?
But the recovery remains weak by historical standards. Four years after a recession, pent-up demand typically produces a strong rebound in growth and a?sustained hiring spree by employers. So far, that hasn?t happened.?
Most forecasters expect the slow steady pace of expansion to continue through this year and into 2014, with the unemployment rate gradually falling.?
The consensus sees GDP picking up to a 2.7 percent annual rate by the end of this year and 3.0 percent by the end of 2014, according to the latest survey by Blue Chip Economic Indicators. That pace is expected to pull the unemployment rate down to 7.5 percent by the end of this year and to 7.0 percent by the end of next year.
If that scenario plays out, it will be awhile before the Fed reaches its 6.5 percent jobless rate target and begins to throttle back its money-making machinery. ? ? ? ??
?At some point were going to have to wean ourselves off that kind of support,? said Fratto. ?And I think we?re going to see that this year. But we have to go through that ? and it?s going to bode well for the future.?
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The new Congress is showing signs that it may finally leave behind its old habit of doing nothing: A gang of eight senators from both parties has outlined a framework for comprehensive immigration reform. While progress could get bogged down in details as the legislation comes together, the bipartisan love fest bodes well for tech companies eager to hire more high-skilled immigrants.Source: http://feedproxy.google.com/~r/Techcrunch/~3/xjW2-dNxf-Y/
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Public release date: 27-Jan-2013
Share ] Contact: Yasmin Anwar
yanwar@berkeley.edu
510-643-7944
University of California - Berkeley
The connection between poor sleep, memory loss and brain deterioration as we grow older has been elusive. But for the first time, scientists at the University of California, Berkeley, have found a link between these hallmark maladies of old age. Their discovery opens the door to boosting the quality of sleep in elderly people to improve memory.
UC Berkeley neuroscientists have found that the slow brain waves generated during the deep, restorative sleep we typically experience in youth play a key role in transporting memories from the hippocampus which provides short-term storage for memories to the prefrontal cortex's longer term "hard drive."
However, in older adults, memories may be getting stuck in the hippocampus due to the poor quality of deep 'slow wave' sleep, and are then overwritten by new memories, the findings suggest.
"What we have discovered is a dysfunctional pathway that helps explain the relationship between brain deterioration, sleep disruption and memory loss as we get older and with that, a potentially new treatment avenue," said UC Berkeley sleep researcher Matthew Walker, an associate professor of psychology and neuroscience at UC Berkeley and senior author of the study to be published this Sunday, Jan. 27, in the journal Nature Neuroscience.
The findings shed new light on some of the forgetfulness common to the elderly that includes difficulty remembering people's names.
"When we are young, we have deep sleep that helps the brain store and retain new facts and information," Walker said. "But as we get older, the quality of our sleep deteriorates and prevents those memories from being saved by the brain at night."
Healthy adults typically spend one-quarter of the night in deep, non-rapid-eye-movement (REM) sleep. Slow waves are generated by the brain's middle frontal lobe. Deterioration of this frontal region of the brain in elderly people is linked to their failure to generate deep sleep, the study found.
The discovery that slow waves in the frontal brain help strengthen memories paves the way for therapeutic treatments for memory loss in the elderly, such as transcranial direct current stimulation or pharmaceutical remedies. For example, in an earlier study, neuroscientists in Germany successfully used electrical stimulation of the brain in young adults to enhance deep sleep and doubled their overnight memory.
UC Berkeley researchers will be conducting a similar sleep-enhancing study in older adults to see if it will improve their overnight memory. "Can you jumpstart slow wave sleep and help people remember their lives and memories better? It's an exciting possibility," said Bryce Mander, a postdoctoral fellow in psychology at UC Berkeley and lead author of this latest study.
For the UC Berkeley study, Mander and fellow researchers tested the memory of 18 healthy young adults (mostly in their 20s) and 15 healthy older adults (mostly in their 70s) after a full night's sleep. Before going to bed, participants learned and were tested on 120 word sets that taxed their memories.
As they slept, an electroencephalographic (EEG) machine measured their brain wave activity. The next morning, they were tested again on the word pairs, but this time while undergoing functional and structural Magnetic Resonance Imaging (fMRI) scans.
In older adults, the results showed a clear link between the degree of brain deterioration in the middle frontal lobe and the severity of impaired "slow wave activity" during sleep. On average, the quality of their deep sleep was 75 percent lower than that of the younger participants, and their memory of the word pairs the next day was 55 percent worse.
Meanwhile, in younger adults, brain scans showed that deep sleep had efficiently helped to shift their memories from the short-term storage of the hippocampus to the long-term storage of the prefrontal cortex.
###
Co-authors of the study are William Jagust, Vikram Rao, Jared Saletin and John Lindquist of UC Berkeley; Brandon Lu of the California Pacific Medical Center and Sonia Ancoli-Israel of UC San Diego.
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Public release date: 27-Jan-2013 Share ] Contact: Yasmin Anwar
yanwar@berkeley.edu
510-643-7944
University of California - Berkeley
The connection between poor sleep, memory loss and brain deterioration as we grow older has been elusive. But for the first time, scientists at the University of California, Berkeley, have found a link between these hallmark maladies of old age. Their discovery opens the door to boosting the quality of sleep in elderly people to improve memory.
UC Berkeley neuroscientists have found that the slow brain waves generated during the deep, restorative sleep we typically experience in youth play a key role in transporting memories from the hippocampus which provides short-term storage for memories to the prefrontal cortex's longer term "hard drive."
However, in older adults, memories may be getting stuck in the hippocampus due to the poor quality of deep 'slow wave' sleep, and are then overwritten by new memories, the findings suggest.
"What we have discovered is a dysfunctional pathway that helps explain the relationship between brain deterioration, sleep disruption and memory loss as we get older and with that, a potentially new treatment avenue," said UC Berkeley sleep researcher Matthew Walker, an associate professor of psychology and neuroscience at UC Berkeley and senior author of the study to be published this Sunday, Jan. 27, in the journal Nature Neuroscience.
The findings shed new light on some of the forgetfulness common to the elderly that includes difficulty remembering people's names.
"When we are young, we have deep sleep that helps the brain store and retain new facts and information," Walker said. "But as we get older, the quality of our sleep deteriorates and prevents those memories from being saved by the brain at night."
Healthy adults typically spend one-quarter of the night in deep, non-rapid-eye-movement (REM) sleep. Slow waves are generated by the brain's middle frontal lobe. Deterioration of this frontal region of the brain in elderly people is linked to their failure to generate deep sleep, the study found.
The discovery that slow waves in the frontal brain help strengthen memories paves the way for therapeutic treatments for memory loss in the elderly, such as transcranial direct current stimulation or pharmaceutical remedies. For example, in an earlier study, neuroscientists in Germany successfully used electrical stimulation of the brain in young adults to enhance deep sleep and doubled their overnight memory.
UC Berkeley researchers will be conducting a similar sleep-enhancing study in older adults to see if it will improve their overnight memory. "Can you jumpstart slow wave sleep and help people remember their lives and memories better? It's an exciting possibility," said Bryce Mander, a postdoctoral fellow in psychology at UC Berkeley and lead author of this latest study.
For the UC Berkeley study, Mander and fellow researchers tested the memory of 18 healthy young adults (mostly in their 20s) and 15 healthy older adults (mostly in their 70s) after a full night's sleep. Before going to bed, participants learned and were tested on 120 word sets that taxed their memories.
As they slept, an electroencephalographic (EEG) machine measured their brain wave activity. The next morning, they were tested again on the word pairs, but this time while undergoing functional and structural Magnetic Resonance Imaging (fMRI) scans.
In older adults, the results showed a clear link between the degree of brain deterioration in the middle frontal lobe and the severity of impaired "slow wave activity" during sleep. On average, the quality of their deep sleep was 75 percent lower than that of the younger participants, and their memory of the word pairs the next day was 55 percent worse.
Meanwhile, in younger adults, brain scans showed that deep sleep had efficiently helped to shift their memories from the short-term storage of the hippocampus to the long-term storage of the prefrontal cortex.
###
Co-authors of the study are William Jagust, Vikram Rao, Jared Saletin and John Lindquist of UC Berkeley; Brandon Lu of the California Pacific Medical Center and Sonia Ancoli-Israel of UC San Diego.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-01/uoc--psi012513.php
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Source: http://video.msnbc.msn.com/nightly-news/50600107/
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Apple's latest Supplier Responsibility Report has just been published, detailing 393 audits focused on the plants and suppliers that help make all that hardware. The audit number is a 72 percent increase in what it covered in its last annual report, while Apple was also quick to highlight its contracting companies' high compliance (92 percent) with a maximum 60-hour work week. Senior vice president of operations Jeff Williams told Reuters that underage workers and limiting working hours were two of the most challenging issues it faced in its supplier audits. Apple decided to end business relations with component maker Guangdong Real Faith Pingzhou Electronics over underage labour issues. "We go deep in the supply chain to find it," said Williams. "And when we do find it, we ensure that the underage workers are taken care of, the suppliers are dealt with."
Via: AllThingsD, Reuters
Source: Apple
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/HTSFhPpvrew/
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The aim of nutritional counseling is to guide a person by helping him or her make and maintain healthy dietary changes. Seeking nutrition counseling can help you with your weight-loss goals by providing you with guidelines and tips on making healthier food choices. This article will explain the ins and outs of nutritional counseling by exploring its effectiveness and how it can aid in weight loss.
What Is Nutritional Counseling?
Nutritional counseling is an ongoing process involving a health professional who works with an individual ? or group ? to assess dietary intake and identify areas where change is needed. One of the most important things is that the health professional and the individual must work together in order to achieve the goals set in place. Below is a list of the types of health professionals who do nutritional counseling:
When choosing whom to work with, you want to ask them about their methods and make sure they are certified.
What Can I Expect to Experience During Nutritional Counseling?
When someone meets with a professional, he or she usually begins with an interview, which involves the professional asking the person questions about his or her typical food intake. Food-frequency questionnaires and other tools may also be used to assess where the individual currently stands in terms of nutrition. The level of questioning depends on the individual. Some people have a good idea of what changes they need to make, or they know they have certain predispositions to illness or illnesses, such as diabetes. Also an individual?s background and situation are also taken into consideration. After gathering all the information, the nutritional counselor works to help prioritize what changes the person needs to make. It?s important to note that dietary changes take time, so an individual might start with a few changes and gradually make more difficult changes. Since the changes take time, counselors might meet with clients for weeks, months or even years. Nutritional counseling might also include these things:
Sometimes family members are encouraged to attend counseling sessions with the client if they share responsibility for food selection and preparation. Having the support and understanding of family members and friends can help someone reach his or her weight-loss goals, although ultimately it is up to the individual.
How Effective Is Nutritional Counseling?
There is strong evidence to support nutritional counseling in making changes in targeted dietary habits, weight and cardiovascular and diabetes risk factors, particularly in individuals with Type 2 Diabetes but also in the general population.
The American Dietetic Association has recommended nutritional counseling for patients at high risk. Also, two panels sponsored by the National Institutes of Health and the National Heart, Lung and Blood Institute have recommended counseling, too. Other organizations that have recognized nutritional counseling include:
Nutritional Counseling Can Help You Lose Weight
Counselors will listen to you and provide you with information to help you understand how important diet really is ? sometimes a little help goes a long way in helping you realize your weight-loss goals.
About the Author: Jenny Fuller is currently studying nutrition and plans to be a nutritionist when she graduates. She first became interested in health after achieving her own weight-loss goals through a Seattle hCG clinic.
Source: http://www.hivehealthmedia.com/nutritional-counseling-weight-loss/
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Public release date: 24-Jan-2013 Share ] Contact: Gina Alvino
galvino@plos.org
Public Library of Science
Researchers at the Paris Cardiovascular Research Center (PARCC) have shown how adhesion of Neisseria (N.) meningitidis to human microvessels in a humanized mouse model leads to the characteristic cutaneous lesions of meningococcal sepsis. This work, published on January 24 in the Open Access journal PLOS Pathogens, is an important demonstration of the direct role of adhesion, specifically Type IV pili mediated adhesion, plays in the development of the disease.
Meningococcal sepsis is a rapidly developing and often fatal infection. Cutaneous lesions, often presenting clinically as purpuric or petechial skin rashes, are a hallmark feature of the infection hence the term purpura fulminans to describe this severe form of sepsis. Understanding the mechanisms behind the development of these lesions is important to understand disease progression because it reveals the underlying mechanisms of the pathological process. From the experimental point of view the strict human specificity of N. meningitidis has long been a limiting factor in the development of relevant in vivo models of this infection and for understanding how the bacteria interact with the blood vessels. It was previously thought that that the large number of circulating bacteria was responsible for the vascular damage through the release of LPS in particular.
In this research, investigators utilized a humanized mouse model, where human skin, containing an abundance of human microvessels, was grafted onto immunocompromised mice. Grafted mice thus had a hybrid vasculature, part mouse, and part human. In this context, N. meningitidis associated exclusively, and in significant numbers, with the human vessels. Once associated with the human vessels the bacteria rapidly led to an endothelial inflammatory response with expression of the human pro-inflammatory cytokines IL-6 and IL-8 and the infiltration of inflammatory cells. Vascular events such as clotting, thrombosis, congestion and vascular leak were all observed in the infected human vessels, mimicking the clinical pathology. The combination of these factors led to the development of a purpuric rash in 30% of the infections. The association of the bacteria with the human vessels was shown to be dependent on the adhesive properties of the bacterial Type IV pili, filamentous structures found at the surface of many pathogenic bacteria. Importantly, bacterial mutants deficient for these adhesive structures do not lead to any distinctive pathology despite normal numbers of circulating bacteria.
This work thus leads to a change in the paradigm in our understanding of the disease mechanism, with local adhesion events now considered central to the disease process. Because it recapitulates key features of human infection, the described experimental model opens new avenues of research to further understand the mechanisms of disease and to design new prevention and treatment strategies.
###
FINANCIAL DISCLOSURE: This study was supported by the following grant agencies: Marie Curie IEF fellowship no. 273223 (KM), ATIP-Avenir Grant from INSERM, CODDIM equipment grant (Ile de France Region), FRM (fondation pour la recherche mdicale) equipment grant, the IBEID Laboratory of excellence consortium, ANR (Agence Nationale pour la Recherche) grant "Bugs-in-flow". The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
COMPETING INTERESTS: The authors have declared that no competing interests exist.
PLEASE ADD THIS LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.plos.org/10.1371/journal.ppat.1003139 (link will go live upon embargo lift)
CITATION: Melican K, Michea Veloso P, Martin T, Bruneval P, Dumnil G (2013) Adhesion of Neisseria meningitidis to Dermal Vessels Leads to Local Vascular Damage and Purpura in a Humanized Mouse Model. PLoS Pathog 9(1): e1003139. doi:10.1371/journal.ppat.1003139
Disclaimer
This press release refers to an upcoming article in PLOS Pathogens. The release is provided by the article authors. Any opinions expressed in these releases or articles are the personal views of the journal staff and/or article contributors, and do not necessarily represent the views or policies of PLOS. PLOS expressly disclaims any and all warranties and liability in connection with the information found in the releases and articles and your use of such information.
Media Permissions
PLOS Journals publish under a Creative Commons Attribution License, which permits free reuse of all materials published with the article, so long as the work is cited (e.g., Kaltenbach LS et al. (2007) Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration. PLoS Genet 3(5): e82. doi:10.1371/journal.pgen.0030082). No prior permission is required from the authors or publisher. For queries about the license, please contact the relative journal contact indicated here: http://www.plos.org/about/media-inquiries/.
About PLOS Pathogens
PLOS Pathogens publishes outstanding original articles that significantly advance the understanding of pathogens and how they interact with their host organisms. All works published in PLOS Pathogens are open access. Everything is immediately available subject only to the condition that the original authorship and source are properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.
About the Public Library of Science
The Public Library of Science (PLOS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 24-Jan-2013 Share ] Contact: Gina Alvino
galvino@plos.org
Public Library of Science
Researchers at the Paris Cardiovascular Research Center (PARCC) have shown how adhesion of Neisseria (N.) meningitidis to human microvessels in a humanized mouse model leads to the characteristic cutaneous lesions of meningococcal sepsis. This work, published on January 24 in the Open Access journal PLOS Pathogens, is an important demonstration of the direct role of adhesion, specifically Type IV pili mediated adhesion, plays in the development of the disease.
Meningococcal sepsis is a rapidly developing and often fatal infection. Cutaneous lesions, often presenting clinically as purpuric or petechial skin rashes, are a hallmark feature of the infection hence the term purpura fulminans to describe this severe form of sepsis. Understanding the mechanisms behind the development of these lesions is important to understand disease progression because it reveals the underlying mechanisms of the pathological process. From the experimental point of view the strict human specificity of N. meningitidis has long been a limiting factor in the development of relevant in vivo models of this infection and for understanding how the bacteria interact with the blood vessels. It was previously thought that that the large number of circulating bacteria was responsible for the vascular damage through the release of LPS in particular.
In this research, investigators utilized a humanized mouse model, where human skin, containing an abundance of human microvessels, was grafted onto immunocompromised mice. Grafted mice thus had a hybrid vasculature, part mouse, and part human. In this context, N. meningitidis associated exclusively, and in significant numbers, with the human vessels. Once associated with the human vessels the bacteria rapidly led to an endothelial inflammatory response with expression of the human pro-inflammatory cytokines IL-6 and IL-8 and the infiltration of inflammatory cells. Vascular events such as clotting, thrombosis, congestion and vascular leak were all observed in the infected human vessels, mimicking the clinical pathology. The combination of these factors led to the development of a purpuric rash in 30% of the infections. The association of the bacteria with the human vessels was shown to be dependent on the adhesive properties of the bacterial Type IV pili, filamentous structures found at the surface of many pathogenic bacteria. Importantly, bacterial mutants deficient for these adhesive structures do not lead to any distinctive pathology despite normal numbers of circulating bacteria.
This work thus leads to a change in the paradigm in our understanding of the disease mechanism, with local adhesion events now considered central to the disease process. Because it recapitulates key features of human infection, the described experimental model opens new avenues of research to further understand the mechanisms of disease and to design new prevention and treatment strategies.
###
FINANCIAL DISCLOSURE: This study was supported by the following grant agencies: Marie Curie IEF fellowship no. 273223 (KM), ATIP-Avenir Grant from INSERM, CODDIM equipment grant (Ile de France Region), FRM (fondation pour la recherche mdicale) equipment grant, the IBEID Laboratory of excellence consortium, ANR (Agence Nationale pour la Recherche) grant "Bugs-in-flow". The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
COMPETING INTERESTS: The authors have declared that no competing interests exist.
PLEASE ADD THIS LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.plos.org/10.1371/journal.ppat.1003139 (link will go live upon embargo lift)
CITATION: Melican K, Michea Veloso P, Martin T, Bruneval P, Dumnil G (2013) Adhesion of Neisseria meningitidis to Dermal Vessels Leads to Local Vascular Damage and Purpura in a Humanized Mouse Model. PLoS Pathog 9(1): e1003139. doi:10.1371/journal.ppat.1003139
Disclaimer
This press release refers to an upcoming article in PLOS Pathogens. The release is provided by the article authors. Any opinions expressed in these releases or articles are the personal views of the journal staff and/or article contributors, and do not necessarily represent the views or policies of PLOS. PLOS expressly disclaims any and all warranties and liability in connection with the information found in the releases and articles and your use of such information.
Media Permissions
PLOS Journals publish under a Creative Commons Attribution License, which permits free reuse of all materials published with the article, so long as the work is cited (e.g., Kaltenbach LS et al. (2007) Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration. PLoS Genet 3(5): e82. doi:10.1371/journal.pgen.0030082). No prior permission is required from the authors or publisher. For queries about the license, please contact the relative journal contact indicated here: http://www.plos.org/about/media-inquiries/.
About PLOS Pathogens
PLOS Pathogens publishes outstanding original articles that significantly advance the understanding of pathogens and how they interact with their host organisms. All works published in PLOS Pathogens are open access. Everything is immediately available subject only to the condition that the original authorship and source are properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.
About the Public Library of Science
The Public Library of Science (PLOS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-01/plos-ppp012213.php
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NEW YORK (Reuters) - California hedge fund manager Doug Whitman was sentenced on Thursday to two years in prison after he became the first defendant in a broad U.S. crackdown on insider trading to take the stand to convince jurors of his innocence.
U.S. District Judge Jed Rakoff in Manhattan imposed the sentence, which was less than half the 4-1/4 to 5-1/4 years that federal prosecutors wanted.
Whitman, the founder of Whitman Capital LLC in Menlo Park, was convicted in August of securities fraud and conspiracy over his involvement in two insider trading schemes between 2006 and 2009.
Prosecutors said one scheme resulted in more than $900,000 of illegal profit from trading the shares of Google Inc
They said the other involved "soft-dollar" payments used to obtain tips on and then trade in chipmaker Marvell Technology Group Ltd
Rakoff said he believed Whitman "repeatedly perjured himself" on the stand and was "willfully, blatantly aware that he was trading on inside information every step of the way."
But he also noted evidence of the defendant's good character, including his assistance to children with learning disabilities, in imposing punishment.
Before learning his punishment, Whitman, 55, choked up as he read from a prepared statement in which the Atherton, California, resident alluded to the breakup of his 20-year marriage soon after he was charged.
"This has been the most painful and shaming experience of my life," Whitman said. "My father taught me not to cut corners and I tried to apply that to my life and my job ... My trial and my conviction have served as a rude and bitter wakeup call."
Whitman was also fined $250,000 and sentenced to one year of supervised release. He was granted bail pending an expected appeal. Federal prosecutor Chris LaVigne said the government will seek a forfeiture of $935,306 of illegal profit.
"Doug Whitman maintains his innocence and looks forward to vindication on appeal," his lawyer David Anderson said in a statement.
Whitman had sought a maximum prison term of six months.
Another of his lawyers, David Rody, told Rakoff that a long sentence was not needed for deterrence, and that prosecuting a "relatively smaller player" such as Whitman was enough to convince others in the hedge fund industry that "nobody's safe."
U.S. Attorney Preet Bharara in New York has obtained well over than 60 guilty pleas and verdicts since publicly revealing his insider trading probe in late 2009.
MULTIPLE INSIDERS
Prosecutors said Whitman tried to make illegal profit with the help of insiders such as Roomy Khan, a former Intel Corp
Also testifying against Whitman was Wesley Wang, a former Whitman Capital employee who later worked at Steven Cohen's SAC Capital Advisors LP.
Khan, Motey and Wang have pleaded guilty to various crimes linked to insider trading. They have been cooperating with investigators with the hope of receiving lighter sentences.
As in many other recent insider trading prosecutions, the government's evidence against Whitman included telephone conversations secretly recorded by the FBI.
Khan was also a central figure in the government's prosecution of Galleon Group LLC hedge fund founder Raj Rajaratnam, a former billionaire who is now serving an 11-year prison sentence for insider trading.
Wang, meanwhile, has given the government information on as many as 20 people who may have been involved in insider trading, prosecutors have said. Among those he named was Dipak Patel, a former SAC portfolio manager.
Rakoff often imposes lesser sentences than the sentencing guidelines recommend and ignored the 10- to 12-month recommended lengthening of Whitman's sentence for perjury.
The judge said that provision could "chill" defendants from defending themselves under oath and be "an impediment to innocent people taking the stand and clearing their name."
In October, Rakoff sentenced former Goldman Sachs Group Inc
The case is U.S. v. Whitman, U.S. District Court, Southern District of New York, No. 12-cr-00125.
(Reporting by Jonathan Stempel in New York; Editing by Tim Dobbyn and Andre Grenon)
Source: http://news.yahoo.com/whitman-capital-founder-gets-two-years-insider-trades-010249263--finance.html
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